Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
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چکیده
منابع مشابه
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.
PG9 is the founder member of an expanding family of glycan-dependent human antibodies that preferentially bind the HIV (HIV-1) envelope (Env) glycoprotein (gp) trimer and broadly neutralize the virus. Here, we show that a soluble SOSIP.664 gp140 trimer constructed from the Clade A BG505 sequence binds PG9 with high affinity (∼11 nM), enabling structural and biophysical characterizations of the ...
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234 words; Text: 7458 words 22 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02749-06 JVI Accepts, published online ahead of print on 4 April 2007
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1217537110